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Cholesterol

Beyond Cholesterol: Emerging Risk Factors for Heart Disease


Medically Reviewed On: November 06, 2003

By Christine Haran

Just when we've mastered the difference between good and bad cholesterol, researchers have introduced a host of new risk factors for heart disease. While the major risk factors such as family history and elevated LDL cholesterol are still the strongest predictors of risk, emerging factors such as high levels of homocysteine and C-reactive protein may also play a role in the development of heart disease. Doctors can now use these extra clues to better determine if patients need treatment and how aggressive the treatment should be.

Below, MacRae F. Linton, MD, a professor of medicine and pharmacology in the division of cardiovascular medicine at Vanderbilt University Medical Center, discusses how heart disease is assessed and when the emerging risk factors should be considered.

What are the major risk factors for coronary artery disease?
The major cardiovascular risk factors can be divided into modifiable and non-modifiable risk factors. The non-modifiable ones include age; for a man, age 45 and for a woman, age 55 or older. Family history, having a parent or sibling who has had premature coronary disease, is another non-modifiable risk factor.

The modifiable risk factors include elevated LDL cholesterol, or the bad cholesterol, and low HDL cholesterol, which is the good cholesterol. Other major risk factors are hypertension, diabetes and cigarette smoking.

How is risk assessed?
According to the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III), you first count the traditional risk factors, and if somebody has fewer than two risk factors, they're at low risk. And if they have two or more risk factors, they're potentially at high risk or intermediate risk. If they already have evidence of coronary disease, they're in the highest risk category. In addition, you are also put in the highest risk category if you have diabetes mellitus, atherosclerosis (plaque build-up) in non-heart blood vessels, or a 10-year risk of coronary heart disease (CHD) events that is greater than 20 percent.

The treatment of hypercholesterolemia is based on the level of LDL cholesterol and risk, so the goal for your LDL cholesterol is determined by your level of risk. For people who are in the highest risk categories, the goal for their LDL cholesterol is less than 100 mg/dL, whereas if you're in the intermediate category, the goal is less than 130 mg/dL, and if you're in the low-risk category, it's less than 160 mg/dL.

What are some lifestyle risk factors?
The lifestyle cardiovascular risk factors are obesity, physical inactivity and a diet that promotes plaque buildup in the arteries; this is basically a high-fat, high-cholesterol typical American diet.

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